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dnaA [2019-01-29 15:15:35]
Molecular weight
50.70 kDa
Product
replication initiation protein
Genomic Context
Categories containing this gene/protein
Gene
The protein
Catalyzed reaction/ biological activity
binds multiple regions in the oriC region, required for recruitment of proteins needed to load the replicative helicase DnaC Protein family
dnaA family (according to Swiss-Prot)Domains
AAA + domainEffectors of protein activity
SirA displaces DnaA from the replication origin PubMedYabA inhibits co-operative binding of DnaA to the oriC DNA PubMedDnaA helix formation (and thus replication initiation) is inhibited by the interaction of either ParA, YabA or DnaN with the AAA domain of DnaA PubMedinteraction with DnaD inhibits the ability of DnaA to cooperatively bind to DNA PubMedDNA gyrase (GyrA-GyrB) inhibits association of DnaA with oriC PubMed Structure
Localization
throughout the cytoplasm PubMedco-localizes with the origin region and replication forks throughout the cell cycle PubMed Expression and Regulation
Operons
Sigma factors
Regulatory mechanism
Regulation
Additional information
term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of dnaA PubMed view in new tabLabs working on this gene/protein
References
Reviews
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The DnaA regulon
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Original publications
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